Nω-Propyl-L-arginine (hydrochloride)

Nω-Propyl-L-arginine (hydrochloride)

• CAS Number: 2321366-46-3
• UNSPSC Description: Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2].
• Target Antigen: NO Synthase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/nω-propyl-l-arginine-hydrochloride.html
• Purity: 98.28
• Solubility: DMSO : 25 mg/mL (ultrasonic;warming)
• Smiles: N[C@@H](CCCNC(NCCC)=N)C(O)=O.[H]Cl
• Molecular Weight: 252.74
• References & Citations: [1]Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40(24):3869-70.|[2]Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported