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A 1070722

CAT: 0804-HY-107531-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107531-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. A 1070722 decreases spontaneous locomotion[1][2].
CAS Number
1384424-80-9
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-1070722.html
Purity
99.87
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=NC(NC(NC2=CC=NC3=C2C=CC(OC)=C3)=O)=CC=C1
Molecular Formula
C17H13F3N4O2
Molecular Weight
362.31
Precautions
H301, H315, H319, H335
References & Citations
[1]Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8 (8) :1697-1703.|[2]Rocca J F. Effect of glycogen synthase kinase-3 inhibition on the acquisition and expression of cocaine-cue conditioned activity and spontaneous locomotion in rodents. Queen's University (Canada), 2014.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β

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