Nylidrin (hydrochloride)

CAT: 0804-HY-B1404-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
CAT#:0804-HY-B1404-01Size:10 mM - 1 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nylidrin hydrochloride (Buphenine hydrochloride) is an orally active β-adrenergic agonist. Nylidrin hydrochloride antagonizes NR1A/2B NMDA receptors (IC50 = 0.18 μM in Xenopus oocytes) . Nylidrin hydrochloride reduces the levels of NP, HA, and M1. Nylidrin hydrochloride has antiviral activity against multiple H1N1 subtype influenza A viruses. Nylidrin hydrochloride improves hemorrhagic shock and anti-allergic effects[1][2][3][4][5].
CAS Number
[849-55-8]
Product Name Alternative
Buphenine hydrochloride
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
IGluR; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Nylidrin-hydrochloride.html
Purity
98.66
Solubility
DMSO : ≥ 41 mg/mL|H2O : 5 mg/mL (ultrasonic)
Smiles
OC(C(NC(C)CCC1=CC=CC=C1)C)C2=CC=C(O)C=C2.[H]Cl
Molecular Formula
C19H26ClNO2
Molecular Weight
335.87
Precautions
H302, H312, H332
References & Citations
[1]A Khandwala, et al. Antiallergic activity of nylidrin hydrochloride (RHC 3432-A) . I. Effect on release of histamine in vitro from rat peritoneal mast cells, guinea pig lung slices and human basophils. International Archives of Allergy & Applied Immunology, 1983, 70 (4) |[2]Boiteau GM, et al. Nylidrin HCl: a beta-sympathetic stimulant in the management of haemorrhagic shock. Can Anaesth Soc J. 1966 May;13 (3) :252-62.|[3]Niemeyer G, et al. Effects of buphenine (nylidrin) on the perfused mammalian eye. Graefes Arch Clin Exp Ophthalmol. 1987;225 (1) :33-8.|[4]Whittemore ER, et al. Subtype-selective antagonism of NMDA receptors by nylidrin. Eur J Pharmacol. 1997 Oct 22;337 (2-3) :197-208.|[5]Jang Y, et al. In Vitro and In Vivo Antiviral Activity of Nylidrin by Targeting the Hemagglutinin 2-Mediated Membrane Fusion of Influenza A Virus. Viruses. 2020 May 25;12 (5) :581.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
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