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Imexon

CAT: 0804-HY-15385-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15385-01Size:5 mg
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Description
Imexon (BM 06002) is an iminopyrrolidone aziridine with anti-cancer activity.
CAS Number
59643-91-3
Product Name Alternative
BM 06002
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Imexon.html
Purity
99.79
Solubility
DMSO : 62.5 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N2CC2C(N)=N1
Molecular Formula
C4H5N3O
Molecular Weight
111.10
Precautions
H315, H319
References & Citations
[1]Sheveleva EV, et al. Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells. Mol Cancer Res. 2012 Mar;10 (3) :392-400.|[2]Samulitis BK, et al. Interaction of dacarbazine and imexon, in vitro and in vivo, in human A375 melanoma cells. Anticancer Res. 2011 Sep;31 (9) :2781-5.|[3]Roman NO, et al. Imexon enhances gemcitabine cytotoxicity by inhibition of ribonucleotide reductase. Cancer Chemother Pharmacol. 2011 Jan;67 (1) :183-92.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

Imexon

Imexon is currently being studied for the treatment of pancreatic, lung, breast, prostate, melanoma, and multiple myeloma cancers. It belongs to the family of drugs called cyanoaziridine derivatives. Also called Amplimexon. Imexon is a cyanoaziridine derivative. Imexon is a thiol-binding small molecule which induces mitochondrial oxidation, a loss of membrane potential and cytochrome C, leading to apoptosis.

CAS Number59643-91-3
PubChem CID68791
IUPAC Name4-amino-1,3-diazabicyclo[3.1.0]hex-3-en-2-one
Molecular FormulaC4H5N3O
Molecular Weight111.10
XLogP-1.4
Topological Polar Surface Area58.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Heavy Atom Count8
Formal Charge0
Complexity186
SMILES
C1C2N1C(=O)N=C2N
InChI
InChI=1S/C4H5N3O/c5-3-2-1-7(2)4(8)6-3/h2H,1H2,(H2,5,6,8)
InChIKey
BIXBBIPTYBJTRY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Imexon
CAS: 59643-91-3
CID: 68791
Formula: C4H5N3O
MW: 111.10
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight111.10
XLogP3-1.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass111.043261792
Monoisotopic Mass111.043261792
Topological Polar Surface Area58.5 Ų
Heavy Atom Count8
Formal Charge0
Complexity186
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3605209-01Imexon
A21306-1Imexon 1mg
A21306-100Imexon 100mg
A21306-10Imexon 10mg
A21306-50Imexon 50mg
A21306-25Imexon 25mg
A21306-5Imexon 5mg

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