Carnosol

• Description :

  Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM[1]. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) [2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; Keap1-Nrf2; Ribosomal S6 Kinase (RSK)

• Type :

  Natural Products

• Related Pathways :

  MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Carnosol.html

• Purity :

  99.90

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1O[C@]2([H])C3=C(C(O)=C(O)C(C(C)C)=C3)[C@@]41CCCC(C)(C)[C@]4([H])C2

• Molecular Formula :

  C20H26O4

• Molecular Weight :

  330.42

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Wang L, et al. Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2. Oncotarget. 2018 Feb 6;9 (76) :34200-34212.|[2]Li X, et al. Carnosol as a Nrf2 Activator Improves Endothelial Barrier Function Through Antioxidative Mechanisms. Int J Mol Sci. 2019;20 (4) :880. Published 2019 Feb 18.|[3]Martin D, et al. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem. 2004;279 (10) :8919-8929.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  RSK2

• CAS Number :

  [5957-80-2]