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Sialyl Lewis A

CAT: 0804-HY-W854385Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W854385Size:1 mg
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Description
Sialyl Lewis A (SLeA) is a carbohydrate-type antigen that can serve as a tumor marker, with upregulation observed in various tumor cells such as cervical cancer, human pancreatic cancer, and colon cancer cells. Sialyl Lewis A is involved in the migration and adhesion of tumor cells. Additionally, elevated expression of Sialyl Lewis A may also lead to pregnancy abnormalities[1][2][3].
CAS Number
92448-22-1
Product Name Alternative
SLeA
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sialyl-lewis-a.html
Smiles
OC([C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)O[C@@H]2[C@H]([C@@H](O[C@@H]([C@@H]2O)CO)O[C@H]([C@H](C=O)NC(C)=O)[C@@H]([C@H](O)CO)O[C@H]3[C@H]([C@@H]([C@@H]([C@@H](O3)C)O)O)O)O)=O
Molecular Formula
C31H52N2O23
Molecular Weight
820.75
References & Citations
[1]Ma Z, et al. Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages. Front Immunol. 2021 May 31;12:679424. |[2]Ugorski M, et al. Sialyl Lewis a: a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells[J]. Acta Biochimica Polonica, 2002, 49 (2) : 303-311.|[3]Takada A, et al. Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium[J]. Cancer research, 1993, 53 (2) : 354-361.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Sialyl Lewis A

3-sialyl lewis is a member of neuraminic acids.

CAS Number92448-22-1
PubChem CID643993
IUPAC Name(2S,4S,5R,6R)-5-acetamido-2-[(2R,3R,4S,5S,6R)-2-[(2R,3R,4R,5R)-2-acetamido-5,6-dihydroxy-1-oxo-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyhexan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
Molecular FormulaC31H52N2O23
Molecular Weight820.7
XLogP-8.6
Topological Polar Surface Area411
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count23
Rotatable Bond Count18
Heavy Atom Count56
Formal Charge0
Complexity1320
SMILES
C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O[C@H]([C@@H](CO)O)[C@@H]([C@H](C=O)NC(=O)C)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O[C@@]3(C[C@@H]([C@H]([C@@H](O3)[C@@H]([C@@H](CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)O
InChI
InChI=1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)54-25(15(42)7-36)24(12(5-34)32-10(2)38)53-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1
InChIKey
INZOTETZQBPBCE-NYLDSJSYSA-N
Chemical Structure
2D Structure
2D structure of Sialyl Lewis A
CAS: 92448-22-1
CID: 643993
Formula: C31H52N2O23
MW: 820.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight820.7
XLogP3-8.6
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count23
Rotatable Bond Count18
Exact Mass820.29608591
Monoisotopic Mass820.29608591
Topological Polar Surface Area411 Ų
Heavy Atom Count56
Formal Charge0
Complexity1320
Isotope Atom Count0
Defined Atom Stereocenter Count20
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
253961CA19-9 (Sialyl Lewis (a), Sialyl Lewis (a), Sialyl Lewisa)
56/51-0001Sialyl-Lewis a
GWB-D3226CSialyl Lewis a Antibody
T35884-01Sialyl-Lewis X
sc-51696Sialyl Lewis a (121SLE)
S1013-51B-01Sialyl Lewis X
C00173-1mg*5Anti-Sialyl-Lewis A
OS00745-013'-Sialyl Lewis A
GTR19274995-01Sialyl Lewis A sodium
abx020612Sialyl-Lewis A Antibody

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