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DKK-1

CAT: 1324-BI-20413Size: 96 TestsDry Ice: NoHazardous: No
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CAT#:1324-BI-20413Size:96 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Intended use: Dickkopf-1 (DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression. DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity. Intended applications: Atherosclerosis Rheumatoid arthritis Myeloma bone disease Diffuse idiopathic skeletal hyperostosis Ankylosing spondylitis Monoclonal gammopathy of undetermined significance Glucocorticoid induced osteoporosis Oncology
Assay Type
ELISA
Sample Volume
20 µL
Detection Range
0 – 160 pmol/L
Sensitivity
1.25 pmol/L (STD2 10 pmol/L)
Species
Human
Incubation Time
3.5 Hours

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