NT-proBNP (1-76)

• Description:

  Intended use: BNP is mainly expressed by ventricular myocardium in response to volume overload and increased filling pressure. BNP has a cleavable signal sequence. Mature BNP consists of 108 amino acids (proBNP or BNP- 108), and undergoes cleavage resulting in physiologically active BNP-32 and additional C-terminal fragments (cf. http://www.uniprot.org/uniprot/P16860#PRO_0000001532), along with a physiologically inactive N- terminal peptide comprising amino acids 1-76, which is further degraded proteolytically. BNP has a key role in cardiovascular homeostasis with biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. A high concentration of BNP in the bloodstream is indicative of heart failure. Intended applications: Cardiac impairment, acute myocardial infarction, (left ventricular dysfunction) Renal failure Obesity and diabetes Various forms of secondary hypertensions Therapy monitoring of heart failure patients

• Assay Type:

  ELISA

• Sample Volume:

  50 μL

• Detection Range:

  0 – 640 pmol/L

• Sensitivity:

  3.3 pmol/L (STD2 10 pmol/L)

• Species:

  Human

• Incubation Time:

  3 H / 30 min