C3a Mouse (TECO®)

CAT: 1324-TE1038Size: 96 TestsDry Ice: NoHazardous: No
CAT#:1324-TE1038Size:96 Tests
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Description
C3 is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue‐specific and is modulated in response to a variety of stimulatory agents. During complement activation, C3 is proteolytically cleaved resulting in release of the anaphylatoxic peptide C3a.   C3a is a small polypeptide consisting of 74 amino acids. C3a itself is very short‐lived and in serum cleaved rapidly into the more stable C3a‐desArg (also called acylation stimulating protein, ASP) . Therefore, measurement of C3a‐desArg allows reliable conclusions about the level of complement activation in the samples.
Assay Type
ELISA
Sample Volume
25 μL (plasma or serum, dilute 1:100)
Detection Range
31 – 500 ng/mL
Sensitivity
LOD: 4.5 ng/mL LLOQ: 0.023 ng/mL
Species
Mouse
Incubation Time
3 Hours

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