Recombinant Human CD48/SLAMF2 Protein (Fc Tag)

• Background:

  Cluster of Differentiation 48 (CD48), also known as SLAMF2 , BCM-1 and BLAST-1 , is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD48. CD48 protein is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 protein performs biological functions in a variety processes including adhesion , pathogen recognition , cellular activation , and cytokine regulation , and emerges as a critical effector molecule in immune responses.

• Abbreviation:

  CD48/SLAMF2

• Synonyms:

  MEM; hCD; mCD; BCM; sgp; TCT; Leukocyte antigen MEM; B-lymphocyte activation marker BLAST; HM48; SLAMF; CD48; BCM1; BLAST; BLAST1; MEM-102; SLAMF2; hCD48; mCD48; BCM1 surface antigen; BLAST-1; B-lymphocyte activation marker BLAST-1; CD48 antigen; HM48-1; Leukocyte antigen MEM-102; MRC OX-45 surface antigen; sgp-60; TCT.1; BCM1; Sgp-60; SLAMF2; Antigen CD48; B cell membrane protein; B lymphocyte activation marker BLAST 1; B-cell activation marker; BCM 1 surface antigen; BLAST 1; CD 48; CD48 antigen (B cell membrane protein) ; CD48 molecule; CD48 protein; Leucocyte antigen MEM 102; MEM 102; MEM102; Signaling lymphocytic activation molecule 2; SLAM family member 2; SLAMF 2

• UniProt:

  P09326

• Accession Number:

  P09326

• Expression System:

  Mammalian

• Tag:

  C-Fc

• Sequence:

  Gln27-Ser220

• Field of Research:

  Immunology

• Endotoxin:

  < 1.0 EU/mg of the protein as determined by the LAL method.

• Purity:

  > 90% as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  46.2 kDa

• Observed Molecular Weight:

  60 kDa

• Formulation:

  Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

• Species:

  Human