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MALAT1-IN-1

CAT: 0804-HY-115579-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115579-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MALAT1-IN-1 (compounds 5) is a potent and specific Malat1 (Metastasis-associated lung adenocarcinoma transcript 1) inhibitor. MALAT1-IN-1 modulated Malat1 downstream genes in a dose-dependent manner without affecting expression of nuclear enriched abundant transcript 1 (Neat1) [1].
CAS Number
827327-28-6
Product Name Alternative
CP 526555-18
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/malat1-in-1.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1C(C2=CC=C(OC)C=C2)=CN=C1NCC3=CC=CC(OC)=C3
Molecular Formula
C19H21N3O2
Molecular Weight
323.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Abulwerdi FA, et al. Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1. ACS Chem Biol. 2019 Feb 15;14 (2) :223-235.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(3-methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine
CAS Number827327-28-6
PubChem CID1096509
IUPAC Name5-(4-methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methylimidazol-2-amine
Molecular FormulaC19H21N3O2
Molecular Weight323.4
XLogP3.4
Topological Polar Surface Area48.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count24
Formal Charge0
Complexity374
SMILES
CN1C(=CN=C1NCC2=CC(=CC=C2)OC)C3=CC=C(C=C3)OC
InChI
InChI=1S/C19H21N3O2/c1-22-18(15-7-9-16(23-2)10-8-15)13-21-19(22)20-12-14-5-4-6-17(11-14)24-3/h4-11,13H,12H2,1-3H3,(H,20,21)
InChIKey
LCVOJBGSGIOMKF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine
CAS: 827327-28-6
CID: 1096509
Formula: C19H21N3O2
MW: 323.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight323.4
XLogP33.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass323.16337692
Monoisotopic Mass323.16337692
Topological Polar Surface Area48.3 Ų
Heavy Atom Count24
Formal Charge0
Complexity374
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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