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KYL peptide

CAT: 0804-HY-P2264-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2264-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC50:4.22 μM, Kd:1.3 μM) . KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses[1][2][3].
CAS Number
676657-00-4
UNSPSC
12352209
Target
Ephrin Receptor
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/kyl-peptide.html
Purity
99.65
Smiles
CC(C)C[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H]1N(C([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H]5N(C([C@H](CC(C)C)NC([C@H](CC6=CC=C(O)C=C6)NC([C@H](CCCCN)N)=O)=O)=O)CCC5)=O)=O)=O)CCC1)=O)=O)=O)=O)=O
Molecular Formula
C74H108N14O17
Molecular Weight
1465.73
References & Citations
[1]Lamberto I, et, al. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem J. 2012 Jul 1;445 (1) :47-56.|[2]Fu AKY, et, al. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111 (27) :9959-64.|[3]Wu B, et.al. HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol. 2013 Jan 24;20 (1) :19-33.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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