Monacolin J

• Description :

  Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.

• Product Name Alternative :

  Antibiotic MB 530A; Lovastatin diol lactone

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; HMG-CoA Reductase (HMGCR)

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/Monacolin_J.html

• Purity :

  99.22

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C[C@H](O)C[C@@H](CC[C@H]2[C@@H](C)C=CC3=C[C@H](C)C[C@H](O)[C@]23[H])O1

• Molecular Formula :

  C19H28O4

• Molecular Weight :

  320.43

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Endo A, et al. Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J Antibiot (Tokyo) . 1985 Mar;38 (3) :420-2.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [79952-42-4]