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W-84 (dibromide)

CAT: 0804-HY-100979-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100979-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
W-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors, which retards [3H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine[1][2][3].
CAS Number
21093-51-6
Product Name Alternative
HDMPPA
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/w-84-dibromide.html
Purity
98.04
Solubility
DMSO : 6.25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 3.03 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[N+](C)(CCCN(C(C1=C2C=CC=C1)=O)C2=O)CCCCCC[N+](C)(CCCN(C(C3=C4C=CC=C3)=O)C4=O)C.[Br-].[Br-]
Molecular Formula
C32H44Br2N4O4
Molecular Weight
708.52
Precautions
H315, H319, H335
References & Citations
[1]Jepsen K, et al. Allosteric stabilization of 3H-N-methylscopolamine binding in guinea-pig myocardium by an antidote against organophosphate intoxication. Pharmacol Toxicol. 1988;63 (3) :163-168.|[2]Mohr K, et al. Equipotent allosteric effect of W84 on [3H]NMS-binding to cardiac muscarinic receptors from guinea-pig, rat, and pig. Pharmacol Toxicol. 1992;70 (3) :198-200.|[3]Grossmüller M, et al. Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2006;372 (4) :267-276.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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