Human CTLA-4 Recombinant Rabbit Monoclonal Antibody [PSH08-13] - BSA and Azide free (Capture)

• Description:

  Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.

• Product Name Alternative:

  ALPS5 CD CD 152 CD152 CD152 antigen CD152 isoform Celiac disease 3 CELIAC3 CTLA 4 CTLA-4 CTLA4 CTLA4_HUMAN Cytotoxic T cell associated 4 Cytotoxic T lymphocyte antigen 4 Cytotoxic T lymphocyte associated 4 Cytotoxic T lymphocyte associated 4, soluble isoform, included Cytotoxic T lymphocyte associated antigen 4 Cytotoxic T lymphocyte associated antigen 4 short spliced form Cytotoxic T lymphocyte associated protein 4 Cytotoxic T lymphocyte associated serine esterase 4 Cytotoxic T lymphocyte protein 4 Cytotoxic T-lymphocyte protein 4 Cytotoxic T-lymphocyte-associated antigen 4 GRD4 GSE ICOS IDDM12 insulin-dependent diabetes mellitus 12 Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 OTTHUMP00000216623

• Abbreviation:

  Cytotoxic T-lymphocyte protein 4 Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) CD152 CTLA4

• Swiss Prot:

  P16410 Human

• Cellular Locus:

  Cell membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Recombinant protein within Human CTLA-4 aa 36-161.

• Isotype:

  IgG

• Clone:

  PSH08-13

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  ELISA (Cap)

• Positive Control:

  Recombinant Human CTLA-4 protein (HA210885).

• Concentration:

  1mg/mL

• Dilution:

  ELISA (Cap): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH08-14] to Human CTLA-4 antibody (Detector) (HA722955) and recombinant Human CTLA-4 protein as the standard (HA210885). The reference range value is 8.2-2,000 pg/ml.

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4).

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3