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Sanggenon G

CAT: 0804-HY-12372-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12372-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP) . Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation[1].
CAS Number
85698-31-3
UNSPSC
12352005
Target
Caspase; IAP
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sanggenon-g.html
Purity
97.23
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=CC(O)=C([C@H]4C=C(CC/C=C(C)/C)C[C@@H](C5=CC=C(O)C=C5O)[C@@H]4C(C6=CC=C(O)C=C6O)=O)C(O)=C13
Molecular Formula
C40H38O11
Molecular Weight
694.72
References & Citations
[1]Seiter MA, et al. Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP) . FEBS Open Bio. 2014 Jul 5;4:659-71.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 8; Caspase 9

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