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N-Acetylmuramic acid

CAT: 0804-HY-W009274-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W009274-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N-acetylmuramic acid is a component of the bacterial cell wall peptidoglycan, essential for maintaining cell shape and integrity[1]. N-acetylmuramic acid inhibits spore germination by inhibiting a coat-associated hexosaminidase and a core enzyme[2]. N-acetylmuramic acid is required by Bacteroides forsythus for proliferation and the maintenance of its cell shape[3]. N-Acetylmuramic acid inhibits the p38 MAPK/NF-κB signaling pathway, and exhibits anti-inflammatory activity. N-Acetylmuramic acid is orally active[4].
CAS Number
10597-89-4
Product Name Alternative
MurNAc; NAMA
UNSPSC
12352200
Hazard Statement
H302, H371
Target
Bacterial; NF-κB; p38 MAPK
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection; MAPK/ERK Pathway; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/n-acetylmuramic-acid.html
Purity
99.9
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
CC(N[C@@H](C=O)[C@@H](O[C@H](C)C(O)=O)[C@H](O)[C@H](O)CO)=O
Molecular Formula
C11H19NO8
Molecular Weight
293.27
Precautions
H302, H371
References & Citations
[1]Herbold DR, Glaser L. Interaction of N-acetylmuramic acid L-alanine amidase with cell wall polymers. J Biol Chem. 1975 Sep 25;250 (18) :7231-8|[2]Brown W, et al. N-acetylmuramic acid inhibits spore germination and germination enzymes. J Basic Microbiol. 1990;30 (2) :67-72|[3]Wyss C. Dependence of proliferation of Bacteroides forsythus on exogenous N-acetylmuramic acid. Infect Immun. 1989 Jun;57 (6) :1757-9|[4]Wu Z, et al. N-acetylmuramic acid triggers anti-inflammatory capacity in LPS-induced RAW 264.7 cells and mice[J]. journal of functional foods, 2015, 13: 108-116.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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