TBK1/IKKε-IN-4
CAT:
804-HY-124652-05
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TBK1/IKKε-IN-4
- CAS Number: 1381930-17-1
- UNSPSC Description: TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR[1].
- Target Antigen: IKK
- Type: Reference compound
- Related Pathways: NF-κB
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/tbk1-ikkε-in-4.html
- Purity: 99.42
- Solubility: DMSO : 70 mg/mL (ultrasonic)
- Smiles: COC1=CC=C(N2N=CC3=CN=C(NC4=CC(OCCCN5CCN(C)CC5)=C(OC)C(OC)=C4)N=C32)C=C1
- Molecular Weight: 533.62
- References & Citations: [1]Ou YH, et al. TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell. 2011 Feb 18;41(4):458-70.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
- Clinical Information: No Development Reported