MID-1

• Description :

  MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake[1].

• Product Name Alternative :

  MLV-6976; NC-1209, MLV-6976 (hydrochloride); NC-1200 (hydrochloride)

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Insulin Receptor

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/mid-1.html

• Purity :

  99.36

• Solubility :

  DMSO : 31.25 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=C(OCC)C=C2

• Molecular Formula :

  C12H11N3O4S

• Molecular Weight :

  293.30

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291 (52) :26627-26635.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [312608-54-1]