2-Methoxyidazoxan (monohydrochloride)

• UNSPSC Description:

  2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2)[1][2].

• Target Antigen:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/2-methoxyidazoxan-monohydrochloride.html

• Purity:

  98.64

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  COC1(C2=NCCN2)OC3=CC=CC=C3OC1.[H]Cl

• Molecular Weight:

  270.71

• References & Citations:

  [1]Head GA. Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents. Ann N Y Acad Sci. 1995;763:531-540.|[2]Trendelenburg AU, et al. Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1996;353(3):245-249.|[3]Sandner G, et al. Effects of caffeine or RX821002 in rats with a neonatal ventral hippocampal lesion. Front Behav Neurosci. 2014;8:15. Published 2014 Jan 28.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  109544-45-8