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DTRIM24

CAT: 0804-HY-111519-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111519-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.
CAS Number
2170695-14-2
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dTRIM24.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic) |Methanol : 150 mg/mL (ultrasonic)
Smiles
CN(C1=C2C=C(C(NS(C3=CC(C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)=O)=O)=O)=CC=C3)(=O)=O)=C1)OC7=CC=CC(OCCC)=C7)C(N2C)=O
Molecular Formula
C55H68N8O13S2
Molecular Weight
1113.30
Precautions
H315, H319, H320
References & Citations
[1]Gechijian LN, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018 Apr;14 (4) :405-412.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

dTRIM24
CAS Number2170695-14-2
PubChem CID131954388
IUPAC Name(2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[[3-[[1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)benzimidazol-5-yl]sulfamoyl]benzoyl]amino]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Molecular FormulaC55H68N8O13S2
Molecular Weight1113.3
XLogP4.8
Topological Polar Surface Area293
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count16
Rotatable Bond Count27
Heavy Atom Count78
Formal Charge0
Complexity2080
SMILES
CCCOC1=CC(=CC=C1)OC2=CC3=C(C=C2NS(=O)(=O)C4=CC=CC(=C4)C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@@H](C[C@H]5C(=O)NCC6=CC=C(C=C6)C7=C(N=CS7)C)O)C(C)(C)C)N(C(=O)N3C)C
InChI
InChI=1S/C55H68N8O13S2/c1-8-20-75-40-12-10-13-41(28-40)76-47-30-45-44(61(6)54(69)62(45)7)29-43(47)60-78(70,71)42-14-9-11-38(26-42)51(66)56-19-21-72-22-23-73-24-25-74-33-48(65)59-50(55(3,4)5)53(68)63-32-39(64)27-46(63)52(67)57-31-36-15-17-37(18-16-36)49-35(2)58-34-77-49/h9-18,26,28-30,34,39,46,50,60,64H,8,19-25,27,31-33H2,1-7H3,(H,56,66)(H,57,67)(H,59,65)/t39-,46+,50-/m1/s1
InChIKey
QUQTXFIMYFMULC-OGOZKGDESA-N
Chemical Structure
2D Structure
2D structure of dTRIM24
CAS: 2170695-14-2
CID: 131954388
Formula: C55H68N8O13S2
MW: 1113.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1113.3
XLogP34.8
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count16
Rotatable Bond Count27
Exact Mass1112.43472660
Monoisotopic Mass1112.43472660
Topological Polar Surface Area293 Ų
Heavy Atom Count78
Formal Charge0
Complexity2080
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
E1143-1mgDTRIM24
A19547-100DTRIM24 100mg
A19547-25DTRIM24 25mg
A19547-50DTRIM24 50mg
A19547-10DTRIM24 10mg
A19547-5DTRIM24 5mg
A19547-1DTRIM24 1mg

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