DTRIM24

CAT: 0957-E1143-1mgSize: 1 mgDry Ice: NoHazardous: No

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CAT#:0957-E1143-1mgSize:1 mg

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CAS Number

2170695-14-2

Molecular Formula

C55H68N8O13S2

Additionnal Information

DTRIM 24 is a is a selective bifunctional degrader of TRIM24 protein, with an IC50 of 337.7 nM. By leveraging the VHL (von Hippel–Lindau) E3 ligase, dTRIM24 induces proteasomal degradation of TRIM24 in a manner dependent on binding both TRIM24’s bromodomain and the VHL complex.

Chemical Information

dTRIM24

CAS Number	2170695-14-2
PubChem CID	131954388
IUPAC Name	(2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[[3-[[1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)benzimidazol-5-yl]sulfamoyl]benzoyl]amino]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Molecular Formula	C55H68N8O13S2
Molecular Weight	1113.3
XLogP	4.8
Topological Polar Surface Area	293
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	27
Heavy Atom Count	78
Formal Charge	0
Complexity	2080

SMILES

CCCOC1=CC(=CC=C1)OC2=CC3=C(C=C2NS(=O)(=O)C4=CC=CC(=C4)C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@@H](C[C@H]5C(=O)NCC6=CC=C(C=C6)C7=C(N=CS7)C)O)C(C)(C)C)N(C(=O)N3C)C

InChI

InChI=1S/C55H68N8O13S2/c1-8-20-75-40-12-10-13-41(28-40)76-47-30-45-44(61(6)54(69)62(45)7)29-43(47)60-78(70,71)42-14-9-11-38(26-42)51(66)56-19-21-72-22-23-73-24-25-74-33-48(65)59-50(55(3,4)5)53(68)63-32-39(64)27-46(63)52(67)57-31-36-15-17-37(18-16-36)49-35(2)58-34-77-49/h9-18,26,28-30,34,39,46,50,60,64H,8,19-25,27,31-33H2,1-7H3,(H,56,66)(H,57,67)(H,59,65)/t39-,46+,50-/m1/s1

InChIKey

QUQTXFIMYFMULC-OGOZKGDESA-N

Chemical Structure

2D Structure

CAS: 2170695-14-2

CID: 131954388

Formula: C55H68N8O13S2

MW: 1113.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	1113.3
XLogP3	4.8
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	27
Exact Mass	1112.43472660
Monoisotopic Mass	1112.43472660
Topological Polar Surface Area	293 Å²
Heavy Atom Count	78
Formal Charge	0
Complexity	2080
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
HY-111519-01	DTRIM24
A19547-100	DTRIM24 100mg
A19547-25	DTRIM24 25mg
A19547-50	DTRIM24 50mg
A19547-10	DTRIM24 10mg
A19547-5	DTRIM24 5mg
A19547-1	DTRIM24 1mg

DTRIM24

Chemical Information

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