Lanosterol-d6

• Description:

  Lanosterol-d6 is deuterium labeled Lanosterol. Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol s

• UNSPSC:

  12352211

• Target:

  Endogenous Metabolite; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]12C3=C (CC[C@@]1 ([C@@] (CC2) ([H]) [C@H] (C) CC/C=C (C ([2H]) ([2H]) [2H]) /C ([2H]) ([2H]) [2H]) C) [C@@]4 ([C@@] (C (C) ([C@H] (CC4) O) C) ([H]) CC3) C

• Molecular Formula:

  C30H44D6O

• Molecular Weight:

  432.75

• References & Citations:

  [1]Upadhyay A, et al. Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. Mol Neurobiol. 2018;55 (2) :1169-1182.|[2]Lee S, et al. Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. Theriogenology. 2016;85 (4) :575-584.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  28290-39-3