Lanosterol-d6

• Description :

  Lanosterol-d6 is deuterium labeled Lanosterol. Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol s

• UNSPSC :

  12352211

• Target :

  Endogenous Metabolite; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Purity :

  99.0

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@]12C3=C(CC[C@@]1([C@@](CC2)([H])[C@H](C)CC/C=C(C([2H])([2H])[2H])/C([2H])([2H])[2H])C)[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC3)C

• Molecular Formula :

  C30H44D6O

• Molecular Weight :

  432.75

• References & Citations :

  [1]Upadhyay A, et al. Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. Mol Neurobiol. 2018;55 (2) :1169-1182.|[2]Lee S, et al. Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. Theriogenology. 2016;85 (4) :575-584.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [28290-39-3]