Lanosterol

• Description :

  Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Lanosterol.html

• Purity :

  99.97

• Solubility :

  Ethanol : 10 mg/mL (ultrasonic)

• Smiles :

  C[C@]12C3=C(CC[C@@]1([C@]([C@H](C)CC/C=C(C)/C)([H])CC2)C)[C@@]4([C@@](C(C)([C@@H](O)CC4)C)([H])CC3)C

• Molecular Formula :

  C30H50O

• Molecular Weight :

  426.72

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Upadhyay A, et al. Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. Mol Neurobiol. 2018;55 (2) :1169-1182.|[2]Lee S, et al. Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. Theriogenology. 2016;85 (4) :575-584.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [79-63-0]