HaloPROTAC-E

• Description :

  HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM. HaloPROTAC-E significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Autophagy; PROTACs; SGK

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Metabolic Enzyme/Protease; PROTAC

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/haloprotac-e.html

• Purity :

  98.76

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1(CC1)C#N)N[C@@H](C(C)(C)C)C(N(C[C@@H]2O)[C@@H](C2)C(NCC(C=CC(C(SC=N3)=C3C)=C4)=C4OCCOCCOCCOCCCCCCCl)=O)=O

• Molecular Formula :

  C39H56ClN5O8S

• Molecular Weight :

  790.41

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Tovell H, Testa A, Maniaci C, et al. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019;14 (5) :882-892.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2365478-58-4]