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HaloPROTAC-E

CAT: 0804-HY-145752-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-145752-01Size:1 mg
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Description
HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM. HaloPROTAC-E significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy.
CAS Number
[2365478-58-4]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Autophagy; PROTACs; SGK
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/haloprotac-e.html
Purity
98.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1(CC1)C#N)N[C@@H](C(C)(C)C)C(N(C[C@@H]2O)[C@@H](C2)C(NCC(C=CC(C(SC=N3)=C3C)=C4)=C4OCCOCCOCCOCCCCCCCl)=O)=O
Molecular Formula
C39H56ClN5O8S
Molecular Weight
790.41
Precautions
H315, H319, H335
References & Citations
[1]Tovell H, Testa A, Maniaci C, et al. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019;14 (5) :882-892.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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