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Neriifolin

CAT: 0804-HY-N8441-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8441-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.
CAS Number
466-07-9
Product Name Alternative
17β-Neriifolin
UNSPSC
12352005
Hazard Statement
H300+H310+H330
Target
Apoptosis; Atg8/LC3; Beclin1; Na+/K+ ATPase
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/neriifolin.html
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@](C4=CC(OC4)=O)([H])CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O)OC)O)([H])CC3)C
Molecular Formula
C30H46O8
Molecular Weight
534.68
Precautions
H300+H310+H330
References & Citations
[1]Keller CW, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114 (52) :E11228-E11237.|[2]Zhao Q, et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82 (5) :735-741.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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