Neriifolin

• Description:

  Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.

• Product Name Alternative:

  17β-Neriifolin

• UNSPSC:

  12352005

• Hazard Statement:

  H300+H310+H330

• Target:

  Apoptosis; Atg8/LC3; Beclin1; Na+/K+ ATPase

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Autophagy; Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/neriifolin.html

• Purity:

  99.70

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@](C4=CC(OC4)=O)([H])CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O)OC)O)([H])CC3)C

• Molecular Formula:

  C30H46O8

• Molecular Weight:

  534.68

• Precautions:

  H300+H310+H330

• References & Citations:

  [1]Keller CW, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114 (52) :E11228-E11237.|[2]Zhao Q, et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82 (5) :735-741.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [466-07-9]