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Butyrolactone 3

CAT: 0804-HY-129039-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129039-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM) . Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases[1][2][3].
CAS Number
778649-18-6
Product Name Alternative
MB-3
UNSPSC
12352005
Hazard Statement
H319
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/butyrolactone-3.html
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](C1=C)[C@@H](CCC)OC1=O)O
Molecular Formula
C9H12O4
Molecular Weight
184.19
Precautions
H319
References & Citations
[1]Biel M, et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.Angew Chem Int Ed Engl. 2004 Jul 26;43 (30) :3974-6|[2]Haque ME, et al. The GCN5: its biological functions and therapeutic potentials. Clin Sci (Lond) . 2021 Jan 15;135 (1) :231-257. |[3]Holmlund T, et al. GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia. Leukemia. 2013 Mar;27 (3) :578-85.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GCN5/PCAF

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