BL-918

• UNSPSC Description:

  BL-918 is an orally active UNC-51-like kinase 1 (ULK1) activator with an EC50 of 24.14 nM. BL-918 exerts its cytoprotective autophagic effect by targeting ULK complex. BL-918 has the potential for Parkinson’s disease (PD) treatment[1].

• Target Antigen:

  Autophagy; ULK

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bl-918.html

• Purity:

  99.98

• Solubility:

  DMSO : ≥ 250 mg/mL

• Smiles:

  O=C(NC1=CC=C(F)C=C1F)[C@H](NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=S)C3=CC=CC=C3

• Molecular Weight:

  533.44

• References & Citations:

  [1]Ouyang L, et al. Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment. J Med Chem. 2018 Apr 12;61(7):2776-2792.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2101517-69-3