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Bradanicline (hydrochloride)

CAT: 0804-HY-18060ASize: 1 EachDry Ice: NoHazardous: No
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Description
Bradanicline hydrochloride (TC-5619 hydrochloride) is the hydrochloride salt form of Bradanicline. Bradanicline hydrochloride is a selective agonist for α7 nicotinic acetylcholine receptor (nAChR), with EC50 of 17 nM for human α7 nAChR and Ki of 1.4 nM. Bradanicline hydrochloride is used for the research of cognitive disorders and schizophrenia[1][2].
CAS Number
1111941-90-2
Product Name Alternative
TC-5619 (hydrochloride)
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bradanicline-hydrochloride.html
Smiles
O=C(N[C@H]1[C@@H](N2CCC1CC2)CC3=CC=CN=C3)C4=CC5=CC=CC=C5O4.Cl
Molecular Formula
C22H24ClN3O2
Molecular Weight
397.90
References & Citations
[1]Mazurov AA, et al. Discovery of (2S,3R) -N-[2- (pyridin-3-ylmethyl) -1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. J Med Chem. 2012;55 (22) :9793-9809. |[2]Hauser TA, et al. TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia. Biochem Pharmacol. 2009;78 (7) :803-812.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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