FN-439 (TFA)

CAT: 0804-HY-100210A-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-100210A-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

FN-439 TFA is a selective collagenase-1 inhibitor. FN-439 TFA inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 TFA can be used for the research of cancer and inflammation[1][2].

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fn-439-tfa.html

Purity

99.81

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

OC(C(F)(F)F)=O.ONC([C@@H](C)NC([C@@H](CC(C)C)NC([C@H]1N(CCC1)C(CNC(C2=CC=C(C=C2)N)=O)=O)=O)=O)=O

Molecular Formula

C25H35F3N6O8

Molecular Weight

604.58

References & Citations

[1]U Benbow, et al. Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid. Clin Exp Metastasis. 1999 May;17 (3) :231-8.|[2]H Anan, et al. Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions. J Endod. 1996 Dec;22 (12) :668-73.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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