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Activated C Subunit

CAT: 0804-HY-153404-02Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153404-02Size:100 mg
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Description
Activated C Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy[1].
CAS Number
956139-21-2
UNSPSC
12352005
Hazard Statement
H314
Target
Biochemical Assay Reagents
Type
Oligonucleotides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/activated-c-subunit.html
Purity
99.64
Solubility
10 mM in DMSO
Smiles
O=C1N=C(NC(C2=CC=CC=C2)=O)C=CN1[C@@H]3O[C@@H](CN(C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)C3)COP(Cl)(N(C)C)=O
Molecular Formula
C37H37ClN5O5P
Molecular Weight
698.15
Precautions
H314
References & Citations
[1]Passini MA, et al. Exon skipping oligomer conjugates for muscular dystrophy. World Intellectual Property Organization, WO2018118599 A1. 2018-06-28.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

Chemical Information

(6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate)
CAS Number956139-21-2
PubChem CID16662132
IUPAC NameN-[1-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]benzamide
Molecular FormulaC37H37ClN5O5P
Molecular Weight698.1
XLogP5.5
Topological Polar Surface Area104
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Heavy Atom Count49
Formal Charge0
Complexity1190
SMILES
CN(C)P(=O)(OC[C@@H]1CN(C[C@@H](O1)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)Cl
InChI
InChI=1S/C37H37ClN5O5P/c1-41(2)49(38,46)47-27-32-25-42(26-34(48-32)43-24-23-33(40-36(43)45)39-35(44)28-15-7-3-8-16-28)37(29-17-9-4-10-18-29,30-19-11-5-12-20-30)31-21-13-6-14-22-31/h3-24,32,34H,25-27H2,1-2H3,(H,39,40,44,45)/t32-,34+,49?/m0/s1
InChIKey
RCQVHNTXMQCQLT-AUIRFOQBSA-N
Chemical Structure
2D Structure
2D structure of (6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate)
CAS: 956139-21-2
CID: 16662132
Formula: C37H37ClN5O5P
MW: 698.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight698.1
XLogP35.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Exact Mass697.2220840
Monoisotopic Mass697.2220840
Topological Polar Surface Area104 Ų
Heavy Atom Count49
Formal Charge0
Complexity1190
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
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T83176-01Activated C Subunit
MBS5824822Activated T Subunit
T83175-01Activated DPG Subunit
489361PRKAB2 (5'-AMP-Activated Protein Kinase Subunit Beta-2, Protein Kinase, AMP-Activated, Beta 2 Non-Catalytic Subunit)
489356PRKAA1 (5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1, Protein Kinase, AMP-Activated, Alpha 1 Catalytic Subunit)
489368PRKAG3 (5'-AMP-Activated Protein Kinase Subunit Gamma-3, Protein Kinase, AMP-Activated, Gamma 3 Non-catalytic Subunit)
489359PRKAB1 (5'-AMP-Activated Protein Kinase Subunit Beta-1, Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit)
489358PRKAA2 (5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2, Protein Kinase, AMP-Activated, Alpha 2 Catalytic Subunit)
AP800995'-AMP-activated protein kinase subunit beta-1

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