Tibenelast sodium

• Description :

  Tibenelast sodium is a phosphodiesterase inhibitor.

• CAS Number :

  [105102-18-9]

• Product Name Alternative :

  LY 186655

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/Tibenelast_(sodium).html

• Purity :

  99.66

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC2=CC(OCC)=C(OCC)C=C2S1)[O-].[Na+]

• Molecular Formula :

  C13H13NaO4S

• Molecular Weight :

  288.29

• References & Citations :

  [1]Schwertschlag US, et al. Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46 (3) :142-7.|[2]Ho PP, et al. Tibenelast, 5,6-diethoxybenzo (B) thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig. Life Sci. 1990;46 (13) :917-25.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2