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Ambuic acid

CAT: 0804-HY-126858Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-126858Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ambuic acid exhibits antimicrobial activity against Staphylococcus aureus, with IC50 of 43.9 μM for strain ATCC 6538. Ambuic acid is an inhbitor for the biosynthesis of cyclic peptide quorum sensing molecules (quormones) in gram-positive bacteria. Ambuic acid exhibits anti-inflammatory activity through ERK/JNK/MAPK signaling pathway[1][2][3].
CAS Number
340774-69-8
Product Name Alternative
(+) -Ambuic acid
UNSPSC
12352005
Target
COX; ERK; JNK; NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ambuic-acid.html
Purity
98.00
Smiles
O=C(O)/C(C)=C/C[C@]12C(C(/C=C/CCCCC)=C(CO)[C@@H](O)[C@@]1([H])O2)=O
Molecular Formula
C19H26O6
Molecular Weight
350.41
References & Citations
[1]Zhang Q, et al., Anti-inflammatory action of ambuic acid, a natural product isolated from the solid culture of Pestalotiopsis neglecta, through blocking ERK/JNK mitogen-activated protein kinase signaling pathway. Exp Ther Med. 2018 Aug;16 (2) :1538-1546.|[2]Nakayama J, et al., Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in gram-positive bacteria. Antimicrob Agents Chemother. 2009 Feb;53 (2) :580-6.|[3]Ding G, et al., Ambuic acid and torreyanic acid derivatives from the endolichenic fungus Pestalotiopsis sp. J Nat Prod. 2009 Jan;72 (1) :182-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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