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ELP1 rabbit pAb

CAT: 0855-ES16757-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16757-01Size:50 µL
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Background
The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Description
The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],
UniProt
O95163
Swiss Prot
O95163
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human ELP1 AA range: 267-317
Target
ELP1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus .
Gene ID (Human)
8518

UniProtKB · O95163

Elongator complex protein 1

ELP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95163
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ELP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ELP1
EC number
—
Processing
—
Secondary accessions
Q5JSV2, Q9H327, Q9UG87
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

CytoplasmNucleus

Disease

Disease variantNeurodegenerationNeuropathy

PTM

Phosphoprotein

Biological process

tRNA processing

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