HSD17B13-IN-12

• UNSPSC Description:

  HSD17B13-IN-12 (Compound 3) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for both leukotriene B3 and estradiol. HSD17B13-IN-12 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI)[1].

• Target Antigen:

  17β-HSD

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/hsd17b13-in-12.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCCC(C)(C)C)C1=C(NC(C2=CC(Cl)=C(O)C=C2)=O)C=CS1

• Molecular Weight:

  380.89

• References & Citations:

  [1]Odingo J, et al. Thiophene hsd17b13 inhibitors and uses thereof. U.S., WO2022020714. 2023-09-07.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2758802-04-7