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Recombinant Human pro-BDNF Protein

CAT: 1676-PR00045Size: 10μg/50μg/500μg/1mgDry Ice: NoHazardous: No
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CAT#:1676-PR00045Size:10μg/50μg/500μg/1mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
Product Name Alternative
Brain-Derived Neurotrophic Factor; BDNF; Abrineurin
Accession Number
P23560
Tag
Tag free
Source
E.coli
Endotoxin
<1 EU/μg as determined by LAL test.
Form
Liquid
Molecular Weight
25.6 KDa
Shipping Conditions
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles and use a manual defrost freezer.
Protein Length
Ala19-Arg247 (R125A, R127A, R128A)
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl,10% Trehalose,10% Glycerol,200mM NaCl,1mM EDTA,0.05% Tween80, pH 7.8.
Species
Human

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