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Cediranib

CAT: 0804-HY-10205-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-10205-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cediranib (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
CAS Number
288383-20-0
Product Name Alternative
AZD2171
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cediranib.html
Purity
99.87
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
FC1=C(OC2=C(C(C=C3OCCCN4CCCC4)=NC=N2)C=C3OC)C=CC5=C1C=C(C)N5
Molecular Formula
C25H27FN4O3
Molecular Weight
450.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Wedge SR, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res, 2005, 65 (10), 4389-4400.|[2]Zhang L, et al. Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas. Sci Signal. 2015 Dec 8;8 (406) :ra125.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PDGFRα; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Citation 01
Biomaterials. 2018 Apr;161:164-178. |Biomed Res Int. 2021 Mar 29:2021:5582648.|Cell Stem Cell. 2019 Sep 5;25 (3) :373-387.e9.|Discov Oncol. 2024 Nov 19;15 (1) :678.|Eur J Pharmacol. 2024 Feb 5:964:176278.|Harvard Medical School LINCS LIBRARY|J Med Chem. 2023 Dec 28;66 (24) :16597-16614.|Neuro Oncol. 2016 Apr;18 (4) :538-48. |Sci Signal. 2015 Dec 8;8 (406) :ra125. |Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.|Life Sci. 2024 Jun 23:122862.

Chemical Information

Cediranib

4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline is an aromatic ether.

CAS Number288383-20-0
PubChem CID9933475
IUPAC Name4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline
Molecular FormulaC25H27FN4O3
Molecular Weight450.5
XLogP4.9
Topological Polar Surface Area72.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity624
SMILES
CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5
InChI
InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3
InChIKey
XXJWYDDUDKYVKI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cediranib
CAS: 288383-20-0
CID: 9933475
Formula: C25H27FN4O3
MW: 450.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight450.5
XLogP34.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass450.20671890
Monoisotopic Mass450.20671890
Topological Polar Surface Area72.5 Ų
Heavy Atom Count33
Formal Charge0
Complexity624
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3603882-01Cediranib
206937Cediranib maleate
MBS386036-01Cediranib (AZD2171)

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