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CSV0C018875 (hydrochloride)

CAT: 0804-HY-133031ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-133031ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CSV0C018875 hydrochloride is a G9a (EHMT2) inhibitor that inhibits G9a activity. CSV0C018875 can effectively inhibit G9a activity in both enzyme and cell-based assays, and its toxicity is much lower than that of the known G9a inhibitor BIX-01294. CSV0C018875 binds tightly to the active site cavity of G9a, thereby improving the binding firmness and prolonging the residence time of the compound, further enhancing the inhibitory effect of G9a. CSV0C018875 has the potential to improve its ADME (absorption, distribution, metabolism and excretion) and pharmacodynamic properties through further optimization[1].
CAS Number
474084-56-5
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/csv0c018875-hydrochloride.html
Smiles
ClC(C=C1)=CC2=C1N=C(C)C=C2NC3=CC=C(OCC)C=C3.Cl
Molecular Formula
C18H18Cl2N2O
Molecular Weight
349.25
References & Citations
[1]M Ramya Chandar Charles, et al. Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening. Biochimie. 2020 Jan;168:220-230.|[2]Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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