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Cyclobuxine D

CAT: 0804-HY-N4080-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4080-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum[1][2].
CAS Number
2241-90-9
UNSPSC
12352211
Target
MAChR
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cyclobuxine-d.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]([C@H](C)NC)([H])[C@H](O)C2)C)[C@@]5([C@@](C([C@@H](NC)CC5)=C)([H])CC3)C4
Molecular Formula
C25H42N2O
Molecular Weight
386.61
References & Citations
[1]. A. Eshonov, et al. Alkaloids of Buxus sempervirens, Crystal and Molecular Structure of Cyclobuxine-D and Imperialine. Chemistry of Natural Compounds. 12 January 2014. 49:11791182.|[2]Kwon, Jun-Tack, et al. Effects of Cyclobuxine D on Drug-Induced Contractions of the Isolated Rat Uterine Muscle and Potassium-Activated Calcium Channels in an Intestinal Smooth Muscle. The Korean Journal of Pharmacology. 1988. 24 (1) : 103-109.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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