ATP

• UNSPSC Description:

  ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[1][2].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ATP.html

• Purity:

  99.62

• Solubility:

  H2O : ≥ 100 mg/mL

• Smiles:

  O=P(O)(O)OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1O)(O)=O)(O)=O

• Molecular Weight:

  507.18

• References & Citations:

  [1]Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.|[2]M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.|[3]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.|[4]Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.. 2022 Nov 4.|ACS Nano. 2023 Nov 21.|Acta Pharmacol Sin. 2022 Jan 12.|Aging (Albany NY). 2021 Mar 10;13(6):8588-8598.|Aging (Albany NY). 2021 Sep 28;13(18):22588-22610.|Anal Chim Acta. 18 October 2021, 339180.|Antioxidants (Basel). 2022, 11(12), 2315.|Antioxidants (Basel). 2023 Jun 19, 12(6), 1304.|Appl Microbiol Biotechnol. 2024 Jan 25;108(1):173.|Arch Oral Biol. 2019 Aug 2;107:104514.|Biochem Biophys Res Commun. 2024 May 14, 708, 149814.|Biochem Pharmacol. 2024 Jun 19:116377.|Biochemistry. 2023 Nov 10.|Biochim Biophys Acta Mol Basis Dis. 2023 Sep 23;166895.|Biochim Biophys Acta Mol Cell Res. 2023 Sep 18;119595.|Biochim Biophys Acta Mol Cell Res. 2024 Mar 22;1871(4):119712.|Biomed Pharmacother. 2024 Jul 15:177:117111.|Biomed Pharmacother. 2024 Jun 21:177:117006.|Biomed Pharmacother. 2024 Jun 24:177:116952.|Bioorgan Med Chem. 2021 Jan 1;29:115899.|bioRxiv. 2024 Apr 21.|Biosens Bioelectron. 2021 Apr 15;178:113025.|Cancer Cell Int. 2023 May 9;23(1):87.|Cancer Lett. 2024 Jul 29:217145.|Carbohyd Polym. 2020 Jun 1;237:116163.|Cell Death Differ. 2021 Sep 11.|Cell Death Dis. 2021 Dec 14;12(12):1159.|Cell Death Dis. 2022 Oct 8;13(10):860.|Cell Death Dis. 2020 Feb 18;11(2):132. |Cell Prolif. 2023 Apr 21;e13442.|Cell Rep. 2021 Aug 10;36(6):109516.|Cell Rep. 2024 Jun 27;43(7):114402.|Clin Oral Investig. 2023 Feb 3.|Crit Care. 2021 Oct 12;25(1):356.|Eur J Pharmacol. 2021 Dec 29;174729.|Eur J Pharmacol. 2023 Mar 24;947:175681.|Front Neurosci. 2022 Jun 7;16:901688.|Heliyon. 2024 Sep 19;10(19):e38050.|Immunity. 2024 Mar 12;57(3):495-512.e11.|Int Immunopharmacol. 2023 Jan 25;116:109747.|Int J Biol Macromol. 2024 Apr 27;268(Pt 2):131779.|Int J Dev Neurosci. 2022 Nov 7.|Int J Mol Sci. 2024 Sep 26;25(19):10366.|J Agric Food Chem. 2024 Sep 16.|J Ethnopharmacol. 2023 Nov 8:117388.|J Ethnopharmacol. 2024 Mar 20:328:118057.|J Transl Med. 2024 Sep 27;22(1):871.|J Virol. 2023 Mar 6;e0000323.|Life Sci. 2021 Feb 9;119192.|Mol Cell. 2022 Apr 14:S1097-2765(22)00290-8.|Mol Cell. 2023 May 19;S1097-2765(23)00324-6.|Mol Immunol. 2024 May:169:86-98.|Nutrients. 2021, 13(12), 4462.|Oral Dis. 2020 Sep 28. |Phytomedicine. 2023 Nov 8, 155193.|Phytomedicine.2023 Sep:118:154971.|Protein Cell. 2021 Oct 22;1-21.|Reprod Biomed Online. 2024 Jun 11.|Res Sq. 2024 Sep 22.|Research Square Preprint. 2021 Jul.|Research Square Preprint. 2022 Feb.|Research Square Preprint. 2022 May.|Research Square Preprint. 2023 Sep 8.|Research Square Preprint. 2024 Apr 9.|Respir Res. 2024 Jul 30;25(1):291.|SSRN. 2023 May 12.|SSRN. 2024 Nov 19.|SSRN. 6 Dec 2022.|Transl Res. 2022.|Cell Death Dis. 2020 Jan 30;11(1):78.|Cell Death Dis. 2023 Mar 1;14(3):174.|Cell Rep. 2024 Sep 28;43(10):114794.|Research Square Preprint. 2020 Dec.|Int Immunopharmacol. 2023 Feb 21;117:109917.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  56-65-5