Recombinant Human IL-18

Recombinant Human IL-18_x000D_ Catalog number: B2018407_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 1 mg_x000D_ Molecular Weight or Concentration: N/A_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -20°C_x000D_ Keywords: Interleukin-18, IL-18_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy Nature. 2020 Jul;583(7817):609-614._x000D_ 2: Jang YS, Lee K, Park M, Joo Park J, Choi GM, Kim C, Dehkohneh SB, Chi S, Han J, Song MY, Han YH, Cha SH, Goo Kang S. Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation Cytokine. 2023 Dec;172:156413._x000D_ 3: Becker-Hapak MK, Shrestha N, McClain E, Dee MJ, Chaturvedi P, Leclerc GM, Marsala LI, Foster M, Schappe T, Tran J, Desai S, Neal CC, Pence P, Wong P, Wagner JA, Russler-Germain DA, Zhu X, Spanoudis CM, Gallo VL, Echeverri CA, Ramirez LL, You L, Egan JO, Rhode PR, Jiao JA, Muniz GJ, Jeng EK, Prendes CA, Sullivan RP, Berrien-Elliott MM, Wong HC, Fehniger TA. A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy Cancer Immunol Res. 2021 Sep;9(9):1071-1087._x000D_ 4: Guo L, Chen X, Zeng H, Tian N, Lu W, Zhang J, Xiao Y. Production of recombinant human long-acting IL-18 binding protein: inhibitory effect on ulcerative colitis in mice Appl Microbiol Biotechnol. 2023 Dec;107(23):7135-7150._x000D_ 5: Baggio C, Bindoli S, Guidea I, Doria A, Oliviero F, Sfriso P. IL-18 in Autoinflammatory Diseases: Focus on Adult Onset Still Disease and Macrophages Activation Syndrome Int J Mol Sci. 2023 Jul 5;24(13):11125._x000D_ 6: Kumagai A, Shimizu K, Kurata R, Cui X, Isagawa T, Harada M, Nagai J, Yoshida Y, Ozaki KI, Takeda N, Semba H, Yonezawa T. Establishment of Novel Cells Stably Secreting Various Human IL-18 Recombinant Proteins Curr Pharm Biotechnol. 2019;20(1):47-55._x000D_ 7: Romberg N, Vogel TP, Canna SW. NLRC4 inflammasomopathies Curr Opin Allergy Clin Immunol. 2017 Dec;17(6):398-404._x000D_ 8: Sun L, Ma W, Gao W, Xing Y, Chen L, Xia Z, Zhang Z, Dai Z. Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome Cell Death Dis. 2019 Jul 17;10(8):542._x000D_ 9: Ding P, Yang R, Li C, Fu HL, Ren GL, Wang P, Zheng DY, Chen W, Yang LY, Mao YF, Yuan HB, Li YH. Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway Crit Care. 2023 May 22;27(1):196._x000D_ 10: Campbell M, Doyle S, Humphries P. IL-18: a new player in immunotherapy for age-related macular degeneration? Expert Rev Clin Immunol. 2014 Oct;10(10):1273-5. _x000D_ _x000D_ Products Related to Recombinant Human IL-18 can be found at Proteins

9000-83-3

Catalog Number: B2018407 (1 mg)

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