Nimbin

• Description :

  Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier. Nimbin is promising for research of neurodegenerative diseases and viral infections[1][2][3][4].

• UNSPSC :

  12352005

• Target :

  Bacterial; Dengue Virus; Flavivirus; Fungal; Histamine Receptor

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/nimbin.html

• Purity :

  99.59

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@]([C@@H]([C@]1(C(C=C2)=O)C)CC(OC)=O)(C3=C4C)[C@@](O[C@]3([H])C[C@@]4([H])C5=COC=C5)([H])[C@@H]([C@@]1([H])[C@]2(C)C(OC)=O)OC(C)=O

• Molecular Formula :

  C30H36O9

• Molecular Weight :

  540.60

• References & Citations :

  [1]Nalini V Gorantla, et al. Neem Derivatives Inhibits Tau Aggregation. J Alzheimers Dis Rep. 2019 Jun 14;3 (1) :169-178.|[2]P Lavanya, et al. Computational Analysis Reveal Inhibitory Action of Nimbin Against Dengue Viral Envelope Protein. Virusdisease. 2015 Dec;26 (4) :243-54.|[3]Li-Juan Yang, et al. Host-guest System of Nimbin and Beta-Cyclodextrin or Its Derivatives: Preparation, Characterization, Inclusion Mode, and Solubilization. J Agric Food Chem. 2010 Aug 11;58 (15) :8545-52.|[4]Sidhu O P, et al. Variability in triterpenoids (nimbin and salanin) composition of neem among different provenances of India[J]. Industrial Crops and Products, 2004, 19 (1) : 69-75.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [5945-86-8]