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Nimbin

CAT: 0804-HY-N3187-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3187-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier. Nimbin is promising for research of neurodegenerative diseases and viral infections[1][2][3][4].
CAS Number
5945-86-8
UNSPSC
12352005
Target
Bacterial; Dengue Virus; Flavivirus; Fungal; Histamine Receptor
Type
Natural Products
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nimbin.html
Purity
99.59
Solubility
10 mM in DMSO
Smiles
C[C@@]([C@@H]([C@]1(C(C=C2)=O)C)CC(OC)=O)(C3=C4C)[C@@](O[C@]3([H])C[C@@]4([H])C5=COC=C5)([H])[C@@H]([C@@]1([H])[C@]2(C)C(OC)=O)OC(C)=O
Molecular Formula
C30H36O9
Molecular Weight
540.60
References & Citations
[1]Nalini V Gorantla, et al. Neem Derivatives Inhibits Tau Aggregation. J Alzheimers Dis Rep. 2019 Jun 14;3 (1) :169-178.|[2]P Lavanya, et al. Computational Analysis Reveal Inhibitory Action of Nimbin Against Dengue Viral Envelope Protein. Virusdisease. 2015 Dec;26 (4) :243-54.|[3]Li-Juan Yang, et al. Host-guest System of Nimbin and Beta-Cyclodextrin or Its Derivatives: Preparation, Characterization, Inclusion Mode, and Solubilization. J Agric Food Chem. 2010 Aug 11;58 (15) :8545-52.|[4]Sidhu O P, et al. Variability in triterpenoids (nimbin and salanin) composition of neem among different provenances of India[J]. Industrial Crops and Products, 2004, 19 (1) : 69-75.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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