Nimbin

• UNSPSC Description:

  Nimbin is a intermediate limonoid isolated from Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier[1][2][3].

• Target Antigen:

  Bacterial; Dengue virus; Flavivirus; Fungal; Histamine Receptor

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nimbin.html

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]([C@@H]([C@]1(C(C=C2)=O)C)CC(OC)=O)(C3=C4C)[C@@](O[C@]3([H])C[C@@]4([H])C5=COC=C5)([H])[C@@H]([C@@]1([H])[C@]2(C)C(OC)=O)OC(C)=O

• Molecular Weight:

  540.60

• References & Citations:

  [1]Nalini V Gorantla, et al. Neem Derivatives Inhibits Tau Aggregation. J Alzheimers Dis Rep. 2019 Jun 14;3(1):169-178.|[2]P Lavanya, et al. Computational Analysis Reveal Inhibitory Action of Nimbin Against Dengue Viral Envelope Protein. Virusdisease. 2015 Dec;26(4):243-54.|[3]Li-Juan Yang, et al. Host-guest System of Nimbin and Beta-Cyclodextrin or Its Derivatives: Preparation, Characterization, Inclusion Mode, and Solubilization. J Agric Food Chem. 2010 Aug 11;58(15):8545-52.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  5945-86-8