Implitapide

• Description:

  Implitapide (AEGR 427) is a microsomal triglyceride transfer protein (MTP) inhibitor.

• Product Name Alternative:

  AEGR 427

• UNSPSC:

  12352005

• Target:

  Microsomal Triglyceride Transfer Protein (MTP)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Implitapide.html

• Purity:

  99.87

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC1=C(C2=C3C=CC=C2)C(N3CC4=CC=C([C@H](C5CCCC5)C(N[C@H](C6=CC=CC=C6)CO)=O)C=C4)=NC(C)=C1

• Molecular Formula:

  C35H37N3O2

• Molecular Weight:

  531.69

• References & Citations:

  [1]Ueshima K, et al. Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein E knockout mice fed a Western-type diet: involvement of the inhibition of postprandial triglyceride elevation. Biol Pharm Bull. 2005 Feb;28 (2) :247-52.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [177469-96-4]