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SW155246

CAT: 0804-HY-123346-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123346-04Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC50s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases[1].
CAS Number
420092-79-1
UNSPSC
12352005
Hazard Statement
H319
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sw155246.html
Purity
98.04
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C=C1[N+]([O-])=O)S(NC2=CC=C(C3=C2C=CC=C3)O)(=O)=O
Molecular Formula
C16H11ClN2O5S
Molecular Weight
378.79
Precautions
H319
References & Citations
[1]Jessica A Kilgore, et al. Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. J Biol Chem. 2013 Jul 5;288 (27) :19673-84.|[2]José L Medina-Franco, et al. Rationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking. Int J Mol Sci. 2014 Feb 21;15 (2) :3253-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamide
CAS Number420092-79-1
PubChem CID3718032
IUPAC Name4-chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamide
Molecular FormulaC16H11ClN2O5S
Molecular Weight378.8
XLogP3.8
Topological Polar Surface Area121
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity590
SMILES
C1=CC=C2C(=C1)C(=CC=C2O)NS(=O)(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
InChI
InChI=1S/C16H11ClN2O5S/c17-13-6-5-10(9-15(13)19(21)22)25(23,24)18-14-7-8-16(20)12-4-2-1-3-11(12)14/h1-9,18,20H
InChIKey
JDYDEJYIVZNWQU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamide
CAS: 420092-79-1
CID: 3718032
Formula: C16H11ClN2O5S
MW: 378.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight378.8
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass378.0077203
Monoisotopic Mass378.0077203
Topological Polar Surface Area121 Ų
Heavy Atom Count25
Formal Charge0
Complexity590
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4651-50SW155246
A22095-50SW155246 50mg
A22095-10SW155246 10mg
A22095-500SW155246 500mg
A22095-100SW155246 100mg
A22095-25SW155246 25mg
A22095-5SW155246 5mg
A22095-1SW155246 1mg
A22095-10mM-DSW155246 10mM * 1mL in DMSO

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