SW155246

• Description :

  SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC50s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases[1].

• CAS Number :

  [420092-79-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H319

• Target :

  DNA Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sw155246.html

• Purity :

  98.04

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  ClC1=CC=C(C=C1[N+]([O-])=O)S(NC2=CC=C(C3=C2C=CC=C3)O)(=O)=O

• Molecular Formula :

  C16H11ClN2O5S

• Molecular Weight :

  378.79

• Precautions :

  H319

• References & Citations :

  [1]Jessica A Kilgore, et al. Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. J Biol Chem. 2013 Jul 5;288 (27) :19673-84.|[2]José L Medina-Franco, et al. Rationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking. Int J Mol Sci. 2014 Feb 21;15 (2) :3253-61.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported