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Human FGF16 Protein

CAT: 0749-PRP1082-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0749-PRP1082-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FGF16 is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart.
Description
FGF16 is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart.
Product Name Alternative
FGF16; Fibroblast Growth Factor 16; Metacarpal 4-5 Fusion; FGF-16; MF4
Gene ID
8823
Accession Number
O43320
Tag
FGF16
Type
Cytokines and proteins
Applications
No tag
Purity
> 98 % as determined by SDS-PAGE
Activity
Measured by its ability to induce proliferation in Balb/3T3 cells. The ED50 for this effect is 5.997 ng/mL.
Molecular Weight
23.6 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin: <0.1 EU per 1 μg of the protein by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized protein product should be stored desiccated below -18°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (5% HSA , 10%FBS or 0.1%BSA) . Please prevent freeze-thaw cycles
Protein Length
The recombinant Human FGF16 consists of 206 amino acids and predicts a molecular mass of 23.6 kDa.
Formulation
Lyophilized from 20 mM Tris-HCl, 500 mM NaCl, pH8.0
Applications Notes
Human
Other Product Names
FGF16; Fibroblast Growth Factor 16; Metacarpal 4-5 Fusion; FGF-16; MF4
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant protein to a concentration of 0.1-1 mg/mL using the buffer we provided, and keep at room temperature for at least 20 min to fully dissolve. Please avoid vortex vigorously.
Preparation
E. coli
Accession Number URL
https://www.uniprot.org/uniprotkb/O43320/entry#sequences
AA Sequence
Amino acid sequence derived from Human FGF16 (Ala2-Arg207) (O43320) was expressed.

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