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Vamicamide

CAT: 0804-HY-U00079A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-U00079A-01Size:1 mg
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Description
Vamicamide (FK-176) is an orally active competitive mAChR antagonist that inhibits contractions induced by cholinergic nerve stimulation by preventing mAChR agonists from binding to mAChR. Vamicamide exhibits a good anti-bladder spasm effect, with a pA2 value of 6.82 in bladder tissue. Vamicamide can be used in research within the field of neurological diseases[1].
CAS Number
132373-81-0
Product Name Alternative
FK-176
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vamicamide.html
Smiles
O=C(N)[C@@](C1=CC=CC=C1)(C[C@H](N(C)C)C)C2=NC=CC=C2
Molecular Formula
C18H23N3O
Molecular Weight
297.39
References & Citations
[1]Oyasu H, et al. Urinary bladder-selective action of the new antimuscarinic compound vamicamide. Arzneimittelforschung. 1994 Nov;44 (11) :1242-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Vamicamide

a potent anticholinergic drug; structure given in first source; RN given refers to compound with no isomeric designation

CAS Number132373-81-0
PubChem CID65967
IUPAC Name(2R,4R)-4-(dimethylamino)-2-phenyl-2-pyridin-2-ylpentanamide
Molecular FormulaC18H23N3O
Molecular Weight297.4
XLogP2
Topological Polar Surface Area59.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count22
Formal Charge0
Complexity365
SMILES
C[C@H](C[C@@](C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)N(C)C
InChI
InChI=1S/C18H23N3O/c1-14(21(2)3)13-18(17(19)22,15-9-5-4-6-10-15)16-11-7-8-12-20-16/h4-12,14H,13H2,1-3H3,(H2,19,22)/t14-,18-/m1/s1
InChIKey
BWNLUIXQIHPUGO-RDTXWAMCSA-N
Chemical Structure
2D Structure
2D structure of Vamicamide
CAS: 132373-81-0
CID: 65967
Formula: C18H23N3O
MW: 297.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight297.4
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass297.184112366
Monoisotopic Mass297.184112366
Topological Polar Surface Area59.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity365
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5784514Vamicamide
M34731-01(S) -Vamicamide

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