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BI-2536

CAT: 0421-82062-1Size: 25 mgDry Ice: NoHazardous: No
CAT#:0421-82062-1Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BI-2536 is a potent, ATP-competitive, well tolerated and effects Polo-like kinases (Plks) as well as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. BI-2536 has an IC50of 0.83 and 25 nM with PLK1 and BRD4 inhibitor, respectively. BI-2536 also blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50of 3.5 nM and 9.0 nM, respectively. BI-2536 suppresses IFNB (encoding IFN-ß) gene transcription. It also shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells.
CAS Number
755038-02-9
Purity
95%
Format
Solid
Molecular Formula
C28H39N7O3
Shipping Conditions
Room Temperature
Storage Conditions
At least 6 months at -20°C.
Calculated Molecular Weight
521.7 Da

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