Bortezomib

• Description:

  Potent (Ki, 0.6 nM), specific and reversible proteasome inhibitor; no significant inhibitory activity against other enzymes or receptors. Bortezomib inhibits cell proliferation of H460 cells (human non-small cell lung cancer cell lines) with an IC50 of 0.1 µM and has been associated with suppresion of prostate cancer cell lines with an IC90 of 10 nM.

• Purity:

  98% by TLC NMR

• Solubility:

  Soluble in DMSO (up to 50 mg/mL) or in Ethanol (up to 35 mg/mL)

• Molecular Formula:

  C19H25BN4O4

• Shipping Conditions:

  -20°C

• Storage Conditions:

  Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

• Calculated Molecular Weight:

  384.25 Da

• CAS Number:

  179324-69-7