CSF1R Kinase Assay Kit

• Background:

  Colony Stimulating Factor 1 Receptor (CSF1R, also known as CSFR, CD115, and M-CSF-R) is a tyrosine kinase transmembrane receptor activated either by CSF1 (MCSF) or interleukin-34 (IL-34), causing homodimerization and activation of the kinase activity. CSF1R is expressed on the surface of monocytes and macrophages, controlling their growth, survival, or differentiation. A number of tumor cells overexpress the cytokine CSF1, driving the development and survival of Tumor-Associated Macrophages, which in turn suppress the local immune response to the cancer

• Description:

  The CSF1R Kinase Assay Kit is designed to measure CSF1R kinase activity for screening and profiling applications using ADP-Glo® as a detection reagent.Need us to run inhibitor screens or profile your compounds against CSF1R? Check out ourKinase Screening Services.

• UniProt:

  P07333

• Applications:

  Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput screen (HTS) applications.

• Format:

  Catalog #NameAmountStorage79110CSF1R (kinase domain) *30 µg-80°C79334Kinase Assay Buffer 1 (5x) 1.5 ml-20°C79686ATP (500 µM) 50 µl-20°C40217PTK Substrate (Poly-Glu, Tyr 4:1) (10 mg/ml) 50 µl-20°C79696White 96-well plate1Room Temp

• Shipping Conditions:

  -80°C

• Storage Conditions:

  This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.

• Notes:

  Troubleshooting GuideVisitAssay-kits-faqfor detailed troubleshooting instructions. For further questions, please email[email protected]

• Contraindications:

  The final concentration of DMSO in the assay should not exceed 1%.